Local gas flow-volume loops
Aims
V|LF-Spiro3D aims at developing and validating a new modality for spatially resolved, 3D lung structure and function characterization using cost-effective small-footprint, low and very-low MRI technology. 3D MR spirometry is to provide an accessible tool for the early diagnosis, staging, and treatment follow-up of patients suffering from respiratory diseases.
More
Lung function is a central concern in the fight against covid-19. Beyond the pandemic heavy losses and long-term health implications, respiratory diseases represent a major threat for the World Health Organisation. It is one of the leading causes of death worldwide, associated with our way of living and impacting all of society. In V|LF-Spiro3D, reference datasets are being acquired at standard MRI field to produce large sets of normative and training data covering six major respiratory diseases: asthma, chronic obstructive pulmonary diseases, bronchopulmonary dysplasia, cystic fibrosis, and bronchiolitis obliterans syndrome in transplant recipients. V|LF-Spiro3D will then redesign the current MRI architecture to perform 3D MR spirometry at low and very low field by highly-processed MRI throughout the lung while the patient is freely breathing, either lying, sitting, or standing in a light V|LF-MRI system. By prioritizing both technology transfer and innovation, V|LF-Spiro3D aims to build up a one-stop-shop imaging standard for the unrestricted assessment of lung pathophysiology.
Objectives
Acquire
3D MR spirometry datasets at standard field
Develop
3D MR spirometry post-processing workflow
Build
Low- and very-low-field 3D MR spirometry
Investigate
3D MR spirometry impact on patients’ experiences
CONSORTIUM
Partnerships
Based on recent works at Universities Paris-Saclay and Aberdeen, in collaboration with leading MR manufacturer Siemens, SME NMR Service, major French-Dutch hospitals and patient organisations, V|LF-Spiro3D brings together multidisciplinary experts in a patient-oriented approach for both adults and children.
LATEST
Things happening
3D MR Spirometry workshops
April 4, 2024 – 3D MR Spirometry workshops at BioMaps – During the Paris consortium meeting, groups of five to ten people were invited to participate in four workshops at BioMaps (UPSaclay) to cover 3D
FCI system: commissionning
March 28, 2024 – First lung image acquired from FCI system – The new Field-Cycling Imager (FCI) being constructed at the Aberdeen Royal Infirmary has produced its first images, including heart
Immersive-pedagogical sensitive theater
April 4, 2024 – Immersive and pedagogical sensitive theater – In a groundbreaking display of creativity and collaboration, the first day of the V|LF-Spiro3D consortium meeting unfolded with an immersive
Inclusion of asthma and COPD patients
February 6, 2024 –First inclusion of asthma and COPD patients – As part of the gb-spiro3d protocol, we welcomed patients with asthma and COPD. The inclusion of patients with asthma
VLF whole-body scanner installation
March 15, 2024 –VLF whole-body scanner installation in Aberdeen – link: https://www.ghat-art.org.uk/mark-1-the-worlds-first-whole-body-mri-scanner/), the AMT team was happy to start re-installing their very low-field MRI whole-body scanner in a brand new
SPIE Medical Imaging 2024
February 19, 2024 – SPIE Medical Imaging 2024 – Oral paper presentation on MRI data postprocessing in the framework of the V|LF-Spiro 3D project. The presentation wag given at the SPIE Medical
Sequence implementation
March 19, 2024 – Spirometry MR sequence implementation at Foch hospital (1.5 T) – Different MR pusle sequences and reconstruction techniques were tested on healthy volunteers. First images presented at consortium
New recruit in Aberdeen!
April 1, 2024 – New recruit in Aberdeen – Nicholas Senn – April 1, 2024 – AMT was joined by a new post-doctoral fellow! Meet Nick Senn, who will be working
IABM 2024
March 25, 2024 – Artificial Intelligence in Biomedical Imaging Congress (IABM 2024) – On March 25-27, the project V|LF-Spiro3D and particularly Université Paris-Saclay were nicely represented by a group of PhD students who
BioMaps annual seminar
March 22, 2024 – BioMaps annual seminar – From 20 to 22 March, BioMaps (UPSaclay) left the medical imaging laboratory empty to fill Fort-Mahon in the north of France, on the Normandy
Exploring
the Fourier sphere
3D lung dynamic MRI sequentially acquire data in the reciprocal image space along an original adaptative radial trajectory of the Fourier sphere that can be randomly-ordered (AZTEK-shuffle), twisted (AZTEK-Twist), and accelerated (AZTEK-Speed)
Contact
For more about V|LF-Spiro3D
Xavier Maître
Scientific Coordinator
xavier.maitre@universite-paris-saclay.fr
+33 6 64 35 63 98
Nicola Lorè
Project Manager
nicola.lore@universite-paris-saclay.fr
+33 6 99 88 65 31
